Beilstein J. Org. Chem.2012,8, 1849–1857, doi:10.3762/bjoc.8.213
quinoline-3-carboxylicacid ether compounds were obtained in high yields (80–93%) after simple recrystallization from ethanol. The structures assigned to these compounds are confirmed by spectral data and elemental analysis, which were fully consistent with the assigned molecular structure as depicted in
PDF
Graphical Abstract
Scheme 1:
Synthesis of ethyl 2-(chloromethyl)-4-phenylquinoline-3-carboxylate (2).
Beilstein J. Org. Chem.2011,7, 210–217, doi:10.3762/bjoc.7.28
Wentao Gao Jia Liu Yun Jiang Yang Li Institute of Superfine Chemicals, Bohai University, Jinzhou 121000, China 10.3762/bjoc.7.28 Abstract A facile and inexpensive synthesis of a series of novel methylenedioxy-bearing 2-(benzofuran-2-yl)-quinoline-3-carboxylicacid derivatives 3a–h via the one-pot
; methylenedioxy-bearing; one-pot; quinoline-3-carboxylicacid; salicylaldehyde; Introduction
Heterocyclic systems containing a quinoline nucleus are an important group of compounds in medicinal chemistry, and are ubiquitous sub-structures associated with biologically active natural products [1][2][3][4]. Some
compounds exhibited similar spectral characteristics. Elemental analysis was in agreement with the theoretical values.
As shown in Table 1, with the exception of 3g (entry 7), a series of 2-(benzofuran-2-yl)quinoline-3-carboxylicacid derivatives 3 were readily prepared under mild reaction conditions in